Taipei Medical University

Translational Medicine 1: Gene Editing & Molecular Imaging

Taipei Medical University

Translational Medicine 1: Gene Editing & Molecular Imaging

Yi-Fan Chen

Instructor: Yi-Fan Chen

Included with Coursera PlusLearn more

Ask Coursera

Gain insight into a topic and learn the fundamentals.
Intermediate level
Some related experience required
1 week to complete
at 10 hours a week
Flexible schedule
Learn at your own pace
Gain insight into a topic and learn the fundamentals.
Intermediate level
Some related experience required
1 week to complete
at 10 hours a week
Flexible schedule
Learn at your own pace

What you'll learn

  • Explain gene therapy principles and evaluate viral vectors for treating genetic diseases.

  • Analyze glycosylation mechanisms and use glycomics to identify clinical biomarkers.

  • Outline preclinical stages, including animal models, toxicology, and regulatory steps.

  • Evaluate molecular imaging modalities to bridge lab discoveries with clinical practice.

Details to know

Shareable certificate

Add to your LinkedIn profile

Recently updated!

July 2026

Assessments

9 assignments

Taught in English

See how employees at top companies are mastering in-demand skills

 logos of Petrobras, TATA, Danone, Capgemini, P&G and L'Oreal

There are 4 modules in this course

Gene therapy is a technique that introduces genetic material into target cells to prevent or fight diseases. However, delivering these therapeutic genes requires overcoming significant biological barriers, such as the extracellular matrix and endosomal degradation. This module explores the principles and applications of using modified viruses as ideal delivery vehicles, known as viral vectors. It objectively examines the conversion of retroviruses, lentiviruses, adenoviruses, and adeno-associated viruses (AAV) into safe, replication-deficient vectors, highlighting their specific advantages, limitations, and recent clinical successes in treating genetic disorders and cancers.

What's included

7 videos4 readings2 assignments

Introduction to GlycoscienceThis module introduces glycoscience and the structural mechanisms of glycosylation, focusing on how carbohydrates covalently bond with proteins and lipids. Drawing from the authoritative text Essentials of Glycobiology, learners will explore foundational biological processes including N-glycosylation, O-glycosylation, and the functions of lectins. Additionally, the course demonstrates how researchers utilize glycomics as a quantitative tool for identifying viral infections and discovering clinical biomarkers, effectively bridging structural biochemistry with modern translational medicine.

What's included

8 videos3 readings2 assignments

In this module, you will explore the essential process of preclinical development — the critical bridge between laboratory discovery and human clinical trials. You will learn why animal models are used in biomedical research, how to select and generate appropriate disease models, and how different mouse strains and genetic modification techniques are applied in practice. The module also covers key toxicology studies and the regulatory steps required before a drug or medical device can advance to human testing.

What's included

5 videos2 readings2 assignments

This module introduces molecular imaging (MI)— a discipline that visualizes biological processes in living organisms at the cellular and molecular level. Moving beyond conventional anatomy-based imaging, we explore key modalities including PET, fluorescence, and bioluminescence imaging, and examine how each bridges laboratory discovery to clinical practice. Through real research examples spanning cancer detection, drug screening, and immunotherapy monitoring, you will see how molecular imaging is reshaping the way we diagnose and treat disease. Let's begin.

What's included

5 videos2 readings3 assignments1 discussion prompt

Instructor

Yi-Fan Chen
Taipei Medical University
1 Course3 learners

Offered by

Explore more from Basic Science

Why people choose Coursera for their career

Felipe M.

Learner since 2018
"To be able to take courses at my own pace and rhythm has been an amazing experience. I can learn whenever it fits my schedule and mood."

Jennifer J.

Learner since 2020
"I directly applied the concepts and skills I learned from my courses to an exciting new project at work."

Larry W.

Learner since 2021
"When I need courses on topics that my university doesn't offer, Coursera is one of the best places to go."

Chaitanya A.

"Learning isn't just about being better at your job: it's so much more than that. Coursera allows me to learn without limits."

Frequently asked questions